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SANOFI-AVENTIS’S ACOMPLIA TO HAVE HUGE IMPACT ON THE OBESITY DRUG MARKET

Lack of Reimbursement Weighs Down the Market, According to a New Study from Decision Resources

Waltham, Mass.--September 1, 2004--Decision Resources, Inc., one of the world’s leading research and advisory firms focusing on pharmaceutical and health care issues, finds that Sanofi-Aventis’s Acomplia, a novel cannabinoid CB1 receptor antagonist, will have a huge impact on the obesity drug market. According to a new Pharmacor study entitled Obesity, the market will reach $2.3 billion in 2013 primarily driven by the strength of Acomplia's sales. Set to launch in 2006, Acomplia is poised to become the first antiobesity agent to achieve blockbuster status.

The study also finds that lack of reimbursement for weigh-loss therapies results in out-of-pocket expenses of approximately $3 per day for two leading antiobesity agents: orlistat (Roche’s Xenical) and sibutramine (Abbott’s Meridia and AstraZeneca’s Reductil).”

“The high cost of these therapies is the top reason for noncompliance and discontinuation of drug therapy,” said Donny Wong, Ph.D., analyst at Decision Resources. “According to physicians that we interviewed, many patients cannot afford to refill their prescriptions. Therefore, a significant commercial opportunity exists for agents that can offer safety and efficacy profiles similar to those of orlistat and sibutramine, but at a reduced cost.”

About Obesity
Metabolic syndrome is a constellation of metabolic abnormalities that are associated with increased risk for cardiovascular disease. These metabolic abnormalities include glucose intolerance, insulin resistance, obesity, type 2 diabetes, dyslipidemia, and hypertension.

About Pharmacor from Decision Resources
Pharmacor is a unique family of studies that assesses a host of market-impacting factors and analyzes the commercial outlook for drugs in research and development.

About Decision Resources
Decision Resources, Inc., (www.decisionresources.com) is a world leader in research publications, advisory services, and consulting designed to help clients shape strategy, allocate resources, and master their chosen markets.

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For more information, contact:
Elizabeth Marshall
Decision Resources, Inc.
781.296.2563

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